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KMID : 0387820090160010049
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Clinical Pediatric Hematology-Oncology
2009 Volume.16 No. 1 p.49 ~ p.53
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A Case of Hemophagocytic Syndrome Induced by Adenovirus Infection after Splenectomy
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Park Sook-Hyun
Lee Kun-Soo
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Abstract
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Hemophagocytic lymphohistiocytosis (HLH) is a rare but sometimes fatal disease. Its main features are prolonged fever, hepatosplenomegaly, cytopenias, and hemophagocytosis in the bone marrow, lymph nodes and other tissues. Hemophagocytic lymphohistiocytosis comprises two different conditions which are: primary, that is with a genetic etiology and secondary, associated with infections, malignancies, and autoimmune diseases. Infection associated hemophagocytic syndrome (IAHS) is caused by bacteria, parasites, fungi, but mostly viruses. A 24 year-old-male, was diagnosed with anaplastic large cell lymphoma and underwent chemotherapy for 6 years because of CNS relapse and leukemic transformation. Thrombocytopenia and splenomegaly persisted after chemotherapy. A splenectomy was done for the treatment of hypersplenism which developed after chemotherapy for anplastic large cell lymphoma, CNS relapse and leukemic transformation. We present a case of hemophagocytic syndrome induced by adenovirus infection after splenectomy.
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KEYWORD
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Hemophagocytic lymphohistiocytosis, Adenovirus, Anaplastic large cell lymphoma, CNS relapse, Hypersplenism, Splenectomy
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